Model-free arterial spin labeling quantification approach for perfusion MRI
نویسندگان
چکیده
منابع مشابه
Prematurity and brain perfusion: Arterial spin labeling MRI
PURPOSE Abnormal brain perfusion is a critical mechanism in neonatal brain injury. The aim of the present study was to compare Cerebral Blood Flow (CBF) evaluated with ASL MRI in three groups of neonates: preterms without brain lesions on MRI (PN), preterms with periventricular white matter lesions (PNp) and term neonates with normal MRI (TN). The correlation between CBF and clinical outcome wa...
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Perfusion is a physiological parameter that refers to the delivery of oxygen and nutrients to tissues via the flow of blood (1). Cerebral blood flow (CBF) is generally quantified in terms of milliliters of blood per gram of tissue per second ml/g/sec (2). Perfusion measurements provide information regarding tissue viability and function, and are therefore of fundamental significance in the fiel...
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A model of the signal path in arterial spin labeling (ASL)-based functional magnetic resonance imaging (fMRI) is presented. Three subtraction-based methods for forming a perfusion estimate are considered and shown to be specific cases of a generalized estimate consisting of a modulator followed by a low pass filter. The performance of the methods is evaluated using the signal model. Contaminati...
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Perfusion refers to the delivery of oxygen and nutrients to tissues by means of blood flow and is one of the most fundamental physiological parameters. Disorders of perfusion also account for most of the leading causes of medical disability and mortality. While measurements of perfusion are of direct diagnostic value in vascular disorders, perfusion measurements also serve as biomarkers for a b...
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Delay 2 s Fig. 1. ASL experiment from a volunteer at 1.5T. (a) The imaging slice and labeling slab are depicted by yellow and blue boxes. (b) Fat-saturated SPGR image. Perfusion images are shown in (c-e) for delay times of 1 s, 1.5 s and 2 s. Arteries located close to the skin are depicted well; however, perfusion in glandular tissue is hardly visible. The yellow arrow shows an artery which doe...
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ژورنال
عنوان ژورنال: Magnetic Resonance in Medicine
سال: 2006
ISSN: 0740-3194,1522-2594
DOI: 10.1002/mrm.20784